Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907425 | 0.90 | CHEK1 (0.48) | BRD4PTGS2JAK2CAMKK2MAPK13 | |
| SCHEMBL12907173 | 0.85 | JAK2 (0.60) | JAK2LRRK2JAK1TYK2JAK3 | |
| SCHEMBL12907191 | 0.77 | JAK2 (0.60) | MKNK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL27968550 | 0.77 | MKNK1 (0.71) | MKNK1JAK2CHEK1CDK4CCNA2 | |
| SCHEMBL12907440 | 0.76 | JAK2 (0.48) | MKNK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12907416 | 0.73 | CHEK1 (0.49) | MKNK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL27565878 | 0.73 | MKNK1 (0.57) | MKNK1JAK2MAPK14CHEK1CDK4 | |
| SCHEMBL12907469 | 0.72 | JAK2 (0.53) | MKNK1JAK2CHEK1CDK4CCNA2 | |
| SCHEMBL18190547 | 0.72 | BRD4 (0.50) | BRD4PTGS2ABL1FFAR4NCOA1 | |
| SCHEMBL12907240 | 0.71 | JAK2 (0.63) | JAK2JAK1TYK2JAK3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |