Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907178 | 0.84 | JAK2 (0.63) | CHEK1PAK1MAPK1MAPKAPK2JAK2 | |
| SCHEMBL12907440 | 0.81 | JAK2 (0.48) | PAK1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL18271123 | 0.77 | FGFR2 (0.76) | MAPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL27968550 | 0.76 | MKNK1 (0.71) | CHEK1MAP2K4JAK2MKNK1CYP1A2 | |
| SCHEMBL6855076 | 0.74 | AKT1 (0.52) | CHEK1PAK1MAPK1MAPKAPK2JAK2 | |
| SCHEMBL12907412 | 0.73 | BRD4 (0.46) | CHEK1PAK1JAK2JAK1TYK2 | |
| SCHEMBL15637885 | 0.72 | JAK2 (0.48) | PAK1MAP2K4JAK2JAK1TYK2 | |
| SCHEMBL12907439 | 0.71 | MAPK1 (0.59) | CHEK1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL5476788 | 0.71 | JAK2 (0.47) | PAK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12907433 | 0.71 | MKNK1 (0.51) | CHEK1MAP2K4MAPK1MAPKAPK2MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |