Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.71 |
| ▸ | JAK2 | O60674 | 4/20 | 0.67 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19188029 | 0.87 | JAK2 (0.57) | MKNK1JAK2AXLCLK2DYRK1A | |
| SCHEMBL12907457 | 0.86 | JAK2 (0.67) | MKNK1JAK2AXLGSK3BGSK3A | |
| SCHEMBL12907439 | 0.84 | MAPK1 (0.59) | MKNK1JAK2GSK3BDYRK1ACHEK1 | |
| SCHEMBL12907433 | 0.83 | MKNK1 (0.51) | MKNK1JAK2GSK3BDYRK1ACDK2 | |
| SCHEMBL29942349 | 0.83 | MAP2K4 (0.64) | MKNK1JAK2GSK3BGSK3ACLK2 | |
| SCHEMBL5508162 | 0.83 | MKNK1 (1.00) | MKNK1JAK2AXLTTKCLK2 | |
| SCHEMBL21509969 | 0.82 | MAP2K4 (0.60) | MKNK1JAK2GSK3BGSK3AGAA | |
| SCHEMBL5430140 | 0.82 | MKNK1 (0.50) | MKNK1JAK2AXLGSK3BGSK3A | |
| SCHEMBL17306449 | 0.81 | MKNK1 (0.87) | MKNK1JAK2AXLGSK3BGSK3A | |
| SCHEMBL22339348 | 0.81 | JAK2 (0.51) | MKNK1JAK2GSK3BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115947690-B | Preparation method of indazole molecular building block and application of indazole molecular building block in drug synthesis | 安徽医科大学 | 2025-04-08 | — | — | CN | disclosed |
| CN-115947690-A | Preparation method of indazole molecular building block and application of building block in drug synthesis | 安徽医科大学 | 2023-04-11 | — | — | CN | disclosed |
| CN-103980280-B | A kind of method of synthetic quinazolinone indazole derivative under acid condition | WENZHOU UNIVERSITY (CN) | 2016-05-04 | — | — | CN | disclosed |
| CN-103664963-B | Method for synthesizing quinazolino indazole derivatives | UNIV WENZHOU | 2015-07-01 | — | — | CN | disclosed |
| CN-103980280-A | Method for synthesizing quinazolino indazole derivatives under acidic condition | UNIV WENZHOU | 2014-08-13 | — | — | CN | disclosed |