SCHEMBL12909282

SCHEMBL12909282

COc1ccc(C)cc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 4/20 0.58
▸ MEN1 O00255 3/20 0.58
▸ POLB P06746 3/20 0.58
▸ KMT2A Q03164 3/20 0.58
▸ ATM Q13315 1/20 0.58
▸ PLEC Q15149 1/20 0.58
▸ L3MBTL1 Q9Y468 2/20 0.56
▸ ALPL P05186 1/20 0.49
▸ ALPI P09923 1/20 0.49
▸ ALPG P10696 1/20 0.49
▸ ALDH1A1 P00352 4/20 0.46
▸ HPGD P15428 3/20 0.46
▸ KDM4E B2RXH2 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ THRB P10828 1/20 0.46
▸ CFTR P13569 1/20 0.46
▸ ALOX12 P18054 1/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12909289 0.89 MEN1 (0.59) USP2MEN1POLBKMT2AATM
SCHEMBL12909284 0.86 USP2 (0.67) USP2MEN1POLBKMT2AATM
SCHEMBL12909281 0.86 USP2 (0.62) USP2MEN1POLBKMT2AATM
SCHEMBL10030600 0.85 USP2 (0.64) USP2MEN1POLBKMT2AATM
SCHEMBL10098714 0.83 USP2 (0.76) USP2MEN1POLBKMT2AATM
SCHEMBL12909292 0.83 MEN1 (0.59) USP2MEN1POLBKMT2AATM
SCHEMBL12045940 0.82 USP2 (0.68) USP2MEN1POLBKMT2AATM
SCHEMBL14646715 0.82 USP2 (0.61) USP2MEN1POLBKMT2AATM
SCHEMBL14044262 0.81 USP2 (0.77) USP2MEN1POLBKMT2AATM
SCHEMBL25024679 0.81 USP2 (0.54) USP2MEN1POLBKMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8309319-B2 Fluorescent probe for measurement of UDP-glucuronosyltransferase THE UNIVERSITY OF TOKYO (JP) 2012-11-13 — — US disclosed
US-8309319-B2 Fluorescent probe for measurement of UDP-glucuronosyltransferase THE UNIVERSITY OF TOKYO (JP) 2012-11-13 — — US disclosed
US-7868147-B2 substantially no fluorescent before the cleavage but highly fluorescent after the cleavage; traps a target substance such as an enzyme and emits fluorescence Nagano, Tetsuo (JP) 2011-01-11 — — US disclosed
US-7868147-B2 substantially no fluorescent before the cleavage but highly fluorescent after the cleavage; traps a target substance such as an enzyme and emits fluorescence Nagano, Tetsuo (JP) 2011-01-11 — — US disclosed
US-20100297681-A1 FLUORESCENT PROBE FOR MEASUREMENT OF GLUCURONATE TRANSFERASE THE UNIVERSITY OF TOKYO (JP) 2010-11-25 — — US disclosed
US-20100297681-A1 FLUORESCENT PROBE FOR MEASUREMENT OF GLUCURONATE TRANSFERASE THE UNIVERSITY OF TOKYO (JP) 2010-11-25 — — US disclosed
US-7524974-B2 Fluorescent probe Nagano, Tetsuo (JP) 2009-04-28 — — US disclosed
US-7524974-B2 Fluorescent probe Nagano, Tetsuo (JP) 2009-04-28 — — US disclosed
US-20080014602-A1 Fluorescent Probe SEKISUI MEDICAL CO., LTD. (JP) 2008-01-17 — — US disclosed
US-20080014602-A1 Fluorescent Probe SEKISUI MEDICAL CO., LTD. (JP) 2008-01-17 — — US disclosed
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