Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10149810 | 0.87 | GAA (0.60) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL12909290 | 0.87 | POLB (0.65) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL10149809 | 0.86 | POLB (0.64) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL10149736 | 0.86 | POLB (0.64) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL10149822 | 0.85 | ALDH1A1 (0.52) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL1658864 | 0.81 | ALDH1A1 (0.61) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL1659183 | 0.81 | KDM4E (0.55) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL1658801 | 0.81 | KDM4E (0.64) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL1658319 | 0.81 | KDM4E (0.57) | KDM4EMAPTGAAALDH1A1POLB | |
| SCHEMBL12898994 | 0.81 | ROCK2 (0.56) | ROCK2ROCK1ATMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011019400-A2 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2011-02-17 | — | — | WO | disclosed |
| WO-2009064422-A2 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | ANGION BIOMEDICA CORP. (US) | 2009-05-22 | — | — | WO | disclosed |