SCHEMBL12911706

SCHEMBL12911706

CC(=O)NNC(=O)c1cc(Cl)c(Cl)c(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.63

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.41
MALT1 Q9UDY8 1/20 0.33
RIPK1 Q13546 1/20 0.32
GRM4 Q14833 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.30
TSHR P16473 1/20 0.30
TRPV1 Q8NER1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12559205 0.91 DHODH (0.40) DHODHMALT1MEN1KMT2AALDH1A1
SCHEMBL12911673 0.90 DHODH (0.42) DHODHMALT1RIPK1GRM4MEN1
SCHEMBL12911643 0.88 DHODH (0.41) DHODHMALT1RIPK1MEN1KMT2A
SCHEMBL12911576 0.88 DHODH (0.43) DHODHMALT1RIPK1MEN1KMT2A
SCHEMBL12911723 0.88 DHODH (0.41) DHODHMALT1RIPK1MEN1KMT2A
SCHEMBL12911644 0.87 DHODH (0.45) DHODHMALT1MEN1KMT2AALDH1A1
SCHEMBL12911637 0.87 DHODH (0.40) DHODHMALT1RIPK1MEN1KMT2A
SCHEMBL12911683 0.87 DHODH (0.49) DHODHMALT1RIPK1
SCHEMBL12911641 0.87 DHODH (0.40) DHODHMALT1MEN1KMT2ATRPV1
SCHEMBL12911684 0.86 DHODH (0.44) DHODHMALT1RIPK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT DHODH 284/4885MALT1 4865/4885RIPK1 3729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.