Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257932 | 1.00 | HSD17B10 (0.42) | HSD17B10TACR3SLC6A7KMT2ASLC18A3 | |
| SCHEMBL6372754 | 1.00 | HSD17B10 (0.42) | HSD17B10TACR3SLC6A7KMT2ASLC18A3 | |
| SCHEMBL1257910 | 0.86 | SMN1; SMN2 (0.55) | HSD17B10SLC6A7SLC18A3PDE10AALDH1A1 | |
| SCHEMBL6372084 | 0.86 | SMN1; SMN2 (0.55) | HSD17B10SLC6A7SLC18A3PDE10AALDH1A1 | |
| SCHEMBL1258711 | 0.86 | SLC6A7 (0.40) | HSD17B10SLC6A7KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL6373463 | 0.86 | SLC6A7 (0.40) | HSD17B10SLC6A7KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL6371864 | 0.83 | GBA1 (0.46) | HSD17B10SLC6A7KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL6373344 | 0.82 | HRH3 (0.49) | HSD17B10SLC6A7KMT2APDE10AALDH1A1 | |
| SCHEMBL1258218 | 0.82 | HRH3 (0.49) | HSD17B10SLC6A7KMT2APDE10AALDH1A1 | |
| SCHEMBL6468876 | 0.81 | MGLL (0.42) | HSD17B10TACR3SLC6A7SLC18A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880002-B2 | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-02-01 | — | — | US | disclosed |