Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 12/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | GLUL | P15104 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13581527 | 0.95 | NR3C1 (0.65) | NR3C1PGRGLUL | |
| SCHEMBL12917991 | 0.87 | NR3C1 (0.59) | NR3C1PGRGLUL | |
| SCHEMBL12917979 | 0.86 | NR3C1 (0.62) | NR3C1PGRGLUL | |
| SCHEMBL12947476 | 0.85 | NR3C1 (0.66) | NR3C1PGRGLUL | |
| SCHEMBL12917976 | 0.85 | NR3C1 (0.66) | NR3C1PGRGLUL | |
| SCHEMBL12917980 | 0.84 | NR3C1 (0.53) | NR3C1GLUL | |
| SCHEMBL12671990 | 0.83 | NR3C1 (0.66) | NR3C1GLUL | |
| SCHEMBL12638273 | 0.83 | NR3C1 (0.66) | NR3C1GLUL | |
| SCHEMBL12918114 | 0.83 | NR3C1 (0.58) | NR3C1PGRGLUL | |
| SCHEMBL12956258 | 0.82 | NR3C1 (0.68) | NR3C1PGRGLUL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338472-B2 | Hexahydrocyclopentyl[F]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338472-B2 | Hexahydrocyclopentyl[F]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20110003797-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE CARBOXAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. | 2011-01-06 | — | — | US | disclosed |
| US-20110003797-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE CARBOXAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003797-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE CARBOXAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, GRK5 | NR3C1 1/4885PGR 334/4885GLUL 2239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.