Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 9/20 | 0.34 |
| ▸ | INSR | P06213 | 7/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473218 | 0.94 | LMNA (0.40) | LMNAPOLBNTRK1MAPK3MAPK1 | |
| SCHEMBL690957 | 0.82 | MAPK3 (0.56) | NTRK1MAPK3MAPK1JAK1TYK2 | |
| SCHEMBL12103291 | 0.80 | MAPK3 (0.45) | MAPK3MAPK1JAK2JAK1TYK2 | |
| SCHEMBL690644 | 0.79 | MAPK3 (0.42) | MAPK3MAPK1METINSRJAK1 | |
| SCHEMBL692085 | 0.75 | MAPK3 (0.57) | MAPK3MAPK1JAK1TYK2MAPK10 | |
| SCHEMBL1293044 | 0.74 | MAPK3 (0.48) | NTRK1MAPK3MAPK1JAK1TYK2 | |
| SCHEMBL12103304 | 0.73 | MAPK1 (0.46) | MAPK3MAPK1JAK2JAK1TYK2 | |
| SCHEMBL691314 | 0.72 | MAPK3 (0.55) | MAPK3MAPK1JAK1TYK2MAPK10 | |
| SCHEMBL12349650 | 0.72 | JAK1 (0.43) | MAPK3MAPK1METINSRJAK2 | |
| SCHEMBL1293095 | 0.72 | MAPK1 (0.43) | MAPK3MAPK1METINSRJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269774-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC | 2011-11-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269774-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | PTK2, PAK1, CTTN | LMNA 4034/4885POLB 2757/4885NTRK1 2279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.