Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 10/20 | 0.35 |
| ▸ | INSR | P06213 | 8/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1293232 | 0.94 | LMNA (0.39) | LMNAPOLBMAPK1MAPK3NTRK1 | |
| SCHEMBL692085 | 0.82 | MAPK3 (0.57) | MAPK1MAPK3JAK1TYK2MAPK10 | |
| SCHEMBL12103304 | 0.79 | MAPK1 (0.46) | MAPK1MAPK3JAK2JAK1TYK2 | |
| SCHEMBL1293095 | 0.78 | MAPK1 (0.43) | MAPK1MAPK3METINSRJAK1 | |
| SCHEMBL690957 | 0.75 | MAPK3 (0.56) | MAPK1MAPK3NTRK1JAK1TYK2 | |
| SCHEMBL1292993 | 0.73 | MAPK3 (0.49) | MAPK1MAPK3JAK2JAK1TYK2 | |
| SCHEMBL691314 | 0.73 | MAPK3 (0.55) | MAPK1MAPK3JAK1TYK2MAPK10 | |
| SCHEMBL12103291 | 0.73 | MAPK3 (0.45) | MAPK1MAPK3JAK2JAK1TYK2 | |
| SCHEMBL12103383 | 0.72 | MAPK3 (0.42) | MAPK1MAPK3METINSRJAK2 | |
| SCHEMBL690644 | 0.72 | MAPK3 (0.42) | MAPK1MAPK3METINSRJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113475-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113475-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | PTK2, PAK1, CTTN | LMNA 4034/4885POLB 2757/4885MAPK1 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.