Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | AHR | P35869 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | CASP1 | P29466 | 3/20 | 0.56 |
| ▸ | CASP7 | P55210 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348744 | 0.87 | KMT2A (0.63) | KMT2AMEN1NR1I2AHRMAPT | |
| SCHEMBL12963526 | 0.84 | MEN1 (0.61) | KMT2AMEN1NR1I2AHRMAPT | |
| SCHEMBL8348445 | 0.81 | KMT2A (0.67) | KMT2AMEN1NR1I2AHRMAPT | |
| SCHEMBL11180483 | 0.75 | MEN1 (0.68) | KMT2AMEN1NR1I2AHRMAPT | |
| SCHEMBL8832163 | 0.74 | MEN1 (1.00) | KMT2AMEN1NR1I2AHRMAPT | |
| SCHEMBL8349393 | 0.73 | MEN1 (0.70) | KMT2AMEN1NR1I2AHRMAPT | |
| SCHEMBL12933512 | 0.72 | PIK3CG (0.47) | KMT2AMEN1LMNAALDH1A1TP53 | |
| SCHEMBL8832269 | 0.71 | KMT2A (0.53) | KMT2AMEN1NR1I2AHRMAPT | |
| SCHEMBL16621922 | 0.71 | MEN1 (0.68) | KMT2AMEN1NR1I2AHRMAPT | |
| Hydrochloric Acid SCHEMBL8832131 | 0.71 | KMT2A (0.52) | KMT2AMEN1NR1I2AHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |