Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9906153 | 1.00 | MAPT (0.53) | MAPTKMT2AATMAPPNPSR1 | |
| SCHEMBL9794436 | 0.83 | MAPT (0.50) | MAPTKMT2AATMAPPNPSR1 | |
| SCHEMBL487465 | 0.82 | MAPT (0.56) | MAPTAPPNPSR1NPC1MTOR | |
| SCHEMBL18561130 | 0.78 | MAPT (0.53) | MAPTAPPKCNH2FFAR1 | |
| SCHEMBL28592261 | 0.78 | MAPT (0.49) | MAPTAPPNPSR1CYP3A4NR1H2 | |
| SCHEMBL523695 | 0.77 | MAPT (0.51) | MAPTKMT2AAPPNPSR1NPC1 | |
| Bicarbonate SCHEMBL28540490 | 0.77 | MAPT (0.51) | MAPTAPPNPSR1NPC1MTOR | |
| Dimethylamine SCHEMBL700542 | 0.77 | MAPT (0.51) | MAPTAPPNPSR1NPC1MTOR | |
| SCHEMBL2183993 | 0.77 | APP (0.55) | MAPTKMT2AAPPNPSR1NPC1 | |
| SCHEMBL562815 | 0.77 | APP (0.55) | MAPTKMT2AAPPNPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283116-B1 | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation | PTC THERAPEUTICS, INC. (US) | 2012-10-09 | — | — | US | claimed |
| US-9394539-B1 | Survival motor neuron gene (SMN2) mRNA constructs for post-transcription regulation | PTC THERAPEUTICS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394539-B1 | Survival motor neuron gene (SMN2) mRNA constructs for post-transcription regulation | PTC THERAPEUTICS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394539-B1 | Survival motor neuron gene (SMN2) mRNA constructs for post-transcription regulation | PTC THERAPEUTICS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-8283116-B1 | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation | PTC THERAPEUTICS, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| US-8283116-B1 | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation | PTC THERAPEUTICS, INC. (US) | 2012-10-09 | — | — | US | disclosed |