Dimethylamine

Dimethylamine

SCHEMBL700542

CC(C)(O)C#Cc1ccccc1.CNC

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.51
ASIC3 Q9UHC3 1/20 0.46
HTT P42858 1/20 0.44
APP P05067 1/20 0.44
LMNA P02545 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PTGES2 Q9H7Z7 2/20 0.41
GRM5 P41594 1/20 0.40
ALDH1A1 P00352 1/20 0.39
HAO1 Q9UJM8 2/20 0.38
TSHR P16473 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
EGFR P00533 1/20 0.36
NPC1 O15118 1/20 0.36
MTOR P42345 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL487465 0.94 MAPT (0.56) MAPTASIC3HTTAPPLMNA
SCHEMBL18561130 0.89 MAPT (0.53) MAPTASIC3HTTAPPLMNA
Bicarbonate SCHEMBL28540490 0.88 MAPT (0.51) MAPTASIC3HTTAPPLMNA
SCHEMBL12391039 0.82 ASIC3 (0.50) MAPTASIC3HTTLMNAL3MBTL1
SCHEMBL3190454 0.79 MAPT (0.47) MAPTASIC3HTTAPPALDH1A1
SCHEMBL11443850 0.78 HAO1 (0.46) MAPTASIC3HTTLMNAL3MBTL1
SCHEMBL2601886 0.77 PTGES2 (0.52) MAPTASIC3HTTPTGES2ALDH1A1
SCHEMBL12935540 0.77 MAPT (0.53) MAPTAPPGRM5NPSR1NPC1
SCHEMBL9906153 0.77 MAPT (0.53) MAPTAPPGRM5NPSR1NPC1
SCHEMBL29116864 0.76 MAPT (0.53) MAPTASIC3HTTAPPLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1688424-B1 PHOSPHONIUM BORATE COMPOUND AND METHOD OF USING THE SAME HOKKO CHEM IND CO (JP) 2016-01-13 EP disclosed
US-8604249-B2 Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2013-12-10 US disclosed
US-8124809-B2 Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2012-02-28 US disclosed
US-20110237799-A1 Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2011-09-29 US disclosed
US-20110166389-A1 Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2011-07-07 US disclosed
US-7728176-B2 Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2010-06-01 US disclosed
US-20090305877-A1 Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2009-12-10 US disclosed
US-20070098616-A1 Process for producing phosponium borate compound, novel phosphonium borate compound, and method of using the same HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2007-05-03 US disclosed
EP-1688424-A1 PROCESS FOR PRODUCING PHOSPHONIUM BORATE COMPOUND, NOVEL PHOSPHONIUM BORATE COMPOUND, AND METHOD OF USING THE SAME HOKKO CHEMICAL INDUSTRY CO. LTD. (JP) 2006-08-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166389-A1 Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same CA4, EPB41, MAPK4 MAPT 2307/4885ASIC3 219/4885HTT 4744/4885
US-20110237799-A1 Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same EPB41, CA4, RBBP4 MAPT 2222/4885ASIC3 222/4885HTT 4591/4885
US-20090305877-A1 Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same PHOSPHO1, BRI3BP, CA4 MAPT 3689/4885ASIC3 214/4885HTT 4628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.