Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847204 | 0.84 | ABCC9 (0.50) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL12935540 | 0.83 | MAPT (0.53) | MAPTNR1H2APPKMT2AATM | |
| SCHEMBL9906153 | 0.83 | MAPT (0.53) | MAPTNR1H2APPKMT2AATM | |
| SCHEMBL8846776 | 0.82 | HSD11B1 (0.57) | NR1H2KMT2ATSHRHSD11B1 | |
| SCHEMBL487465 | 0.79 | MAPT (0.56) | MAPTAPPALDH1A1TSHRNPSR1 | |
| SCHEMBL8525296 | 0.76 | NR1H2 (0.64) | NR1H2TSHRNR1H3 | |
| SCHEMBL18561130 | 0.75 | MAPT (0.53) | MAPTAPPALDH1A1TSHRHTT | |
| SCHEMBL20945461 | 0.74 | NR1H2 (0.58) | MAPTNR1H2NR1I2 | |
| SCHEMBL16439860 | 0.74 | APP (0.50) | MAPTNR1H2APPKMT2ANR1I2 | |
| Bicarbonate SCHEMBL28540490 | 0.73 | MAPT (0.51) | MAPTAPPTSHRNPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983627-A | Treating atherosclerosis, thrombosis and vasospasms; anticholesterol,-secretory,-ulcer and hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1991-01-08 | — | — | US | disclosed |