SCHEMBL1295002

SCHEMBL1295002

C[C@H](CCOc1ccc(S(C)(=O)=O)cc1)C1CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.71
MMP13 P45452 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2432347 0.86 GPR119 (0.51) GPR119MMP13
SCHEMBL1576128 0.85 GPR119 (0.73) GPR119
SCHEMBL2426771 0.85 GPR119 (0.73) GPR119
SCHEMBL1575744 0.84 GPR119 (0.89) GPR119
SCHEMBL1574955 0.83 GPR119 (1.00) GPR119
SCHEMBL2216375 0.80 GPR119 (0.45) GPR119MMP13
SCHEMBL12434644 0.80 GPR119 (0.45) GPR119MMP13
SCHEMBL2216383 0.80 GPR119 (0.45) GPR119MMP13
SCHEMBL12106817 0.80 GPR119 (0.44) GPR119
SCHEMBL26637524 0.80 GPR119 (0.46) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2011-11-03 US disclosed
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2011-11-03 US disclosed
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2011-11-03 US disclosed
EP-2377863-A1 Piperidine GPCR agonists Prosidion Limited (GB) 2011-10-19 EP disclosed
US-20110178054-A1 Heterocyclic GPCR Agonists PROSIDION LIMITED (GB) 2011-07-21 US disclosed
US-20110178054-A1 Heterocyclic GPCR Agonists PROSIDION LIMITED (GB) 2011-07-21 US disclosed
US-20110178054-A1 Heterocyclic GPCR Agonists PROSIDION LIMITED (GB) 2011-07-21 US disclosed
US-20100048632-A1 Piperidine GPCR Agonists PROSIDION LIMITED (GB) 2010-02-25 US disclosed
US-20100048632-A1 Piperidine GPCR Agonists PROSIDION LIMITED (GB) 2010-02-25 US disclosed
WO-2010004343-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2010004348-A1 HETEROCYCLIC GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2008081204-A1 PIPERIDINE GPCR AGONISTS PROSIDION LIMITED (GB) 2008-07-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048632-A1 Piperidine GPCR Agonists GPR119, GPR27, GLP1R GPR119 1/4885MMP13 3760/4885
US-20110178054-A1 Heterocyclic GPCR Agonists GPR119, GCGR, GPR27 GPR119 1/4885MMP13 4293/4885
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS GPR119, GPR27, GLP1R GPR119 1/4885MMP13 3624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.