Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 20/20 | 0.43 |
| ▸ | CDK9 | P50750 | 20/20 | 0.43 |
| ▸ | CDK4 | P11802 | 7/20 | 0.41 |
| ▸ | CCND1 | P24385 | 7/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | CCNH | P51946 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK3 | Q00526 | 4/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050889 | 0.86 | PDE10A (0.44) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL14545193 | 0.84 | CCNT1 (0.54) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL26870870 | 0.75 | PDE10A (0.51) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL26867820 | 0.75 | CCNT1 (0.46) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL26867819 | 0.75 | CCNT1 (0.46) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL26867814 | 0.75 | CCNT1 (0.46) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL13146209 | 0.74 | CDK9 (0.35) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL26874487 | 0.73 | CCNT1 (0.56) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL14043130 | 0.71 | CCNT1 (0.48) | CCNT1CDK9CDK4CCND1CDK7 | |
| SCHEMBL14050765 | 0.70 | CCNT1 (0.53) | CCNT1CDK9CDK4CCND1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| US-7196078-B2 | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPOARTION (US) | 2007-03-27 | — | — | US | disclosed |