Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954471 | 0.89 | GSK3B (0.55) | GSK3BCDK2NPC1RAB9AKMT2A | |
| SCHEMBL13305020 | 0.87 | GSK3B (0.55) | GSK3BCDK2NPC1RAB9AKMT2A | |
| SCHEMBL13305640 | 0.87 | CDK2 (0.54) | GSK3BCDK2NPC1RAB9AKMT2A | |
| SCHEMBL13305342 | 0.87 | CDK2 (0.53) | GSK3BCDK2MAPK14NPC1RAB9A | |
| SCHEMBL12954101 | 0.87 | CDK2 (0.70) | GSK3BCDK2 | |
| SCHEMBL14546042 | 0.85 | GSK3B (0.51) | GSK3BCDK2NPC1RAB9AKMT2A | |
| SCHEMBL14050783 | 0.85 | GSK3B (0.51) | GSK3BCDK2MAPK14NPC1RAB9A | |
| SCHEMBL13305297 | 0.83 | CDK2 (0.77) | GSK3BCDK2NPC1RAB9AKMT2A | |
| SCHEMBL14545972 | 0.82 | GSK3B (0.46) | GSK3BCDK2KMT2AMEN1MAPT | |
| SCHEMBL14545258 | 0.82 | GSK3B (0.46) | GSK3BCDK2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |