Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.65 |
| ▸ | AR | P10275 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16187915 | 0.87 | PARP1 (0.65) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL12955362 | 0.82 | PARP1 (0.70) | PARP1ARENPP1LMNACYP3A4 | |
| SCHEMBL863462 | 0.80 | AR (1.00) | PARP1ARENPP1LMNACYP3A4 | |
| SCHEMBL12955388 | 0.80 | LMNA (0.72) | PARP1ARSMN1; SMN2LMNACYP3A4 | |
| SCHEMBL29655200 | 0.80 | PARP1 (0.70) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL1028195 | 0.80 | PARP1 (0.72) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL4573019 | 0.80 | PARP1 (0.70) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL12798188 | 0.80 | PARP1 (0.70) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL3387433 | 0.80 | PARP1 (0.70) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL26907276 | 0.80 | PARP1 (0.58) | PARP1ARENPP1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330442-B1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARM LTD (GB) | 2011-01-19 | — | — | EP | disclosed |
| US-7750006-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-07-06 | — | — | US | disclosed |