Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 4/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337234 | 0.86 | HCRTR2 (0.71) | HCRTR2ALDH1A1TSHRSMN1; SMN2OXTR | |
| SCHEMBL1040836 | 0.83 | HCRTR2 (1.00) | HCRTR2ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL12956195 | 0.76 | HCRTR2 (0.68) | HCRTR2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL12407757 | 0.72 | RORC (0.62) | ALDH1A1SMN1; SMN2RORCLMNA | |
| SCHEMBL1629149 | 0.72 | HCRTR2 (0.58) | HCRTR2ALDH1A1RORCOXTRKEAP1 | |
| SCHEMBL12481964 | 0.72 | RORC (0.61) | HCRTR2ALDH1A1SMN1; SMN2RORCLMNA | |
| SCHEMBL1041090 | 0.71 | HCRTR2 (1.00) | HCRTR2ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL16557464 | 0.71 | SMN1; SMN2 (0.71) | ALDH1A1SMN1; SMN2RORCOXTRMAPT | |
| SCHEMBL12481129 | 0.70 | PTGER1 (0.61) | RORCMAPT | |
| SCHEMBL1038273 | 0.69 | HCRTR2 (1.00) | HCRTR2ALDH1A1OXTRKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-B1 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-01-26 | — | — | EP | disclosed |