Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | OXTR | P30559 | 4/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12956454 | 0.86 | HCRTR2 (0.71) | HCRTR2TSHRALDH1A1SMN1; SMN2OXTR | |
| SCHEMBL1038273 | 0.83 | HCRTR2 (1.00) | HCRTR2ALDH1A1OXTR | |
| SCHEMBL12956195 | 0.76 | HCRTR2 (0.68) | HCRTR2TSHRALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3401540 | 0.76 | MEN1 (0.63) | TSHRALDH1A1SMN1; SMN2PTGER1MEN1 | |
| SCHEMBL1630148 | 0.75 | HCRTR2 (0.61) | HCRTR2ALDH1A1OXTRMEN1KMT2A | |
| SCHEMBL27996284 | 0.73 | MAPT (0.54) | HCRTR2TSHRALDH1A1SMN1; SMN2OXTR | |
| SCHEMBL12407762 | 0.72 | PTGER1 (0.64) | ALDH1A1SMN1; SMN2PTGER1MEN1KMT2A | |
| SCHEMBL7813073 | 0.72 | KEAP1 (0.68) | HCRTR2ALDH1A1SMN1; SMN2PTGER1MEN1 | |
| SCHEMBL1632612 | 0.72 | HCRTR2 (0.61) | HCRTR2OXTRMEN1KMT2A | |
| SCHEMBL24279540 | 0.71 | ALDH1A1 (0.61) | HCRTR2ALDH1A1SMN1; SMN2OXTRPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-B1 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-01-26 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |