Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23654833 | 0.88 | ALDH1A1 (0.70) | ALDH1A1LMNAMAPTSIRT6MAPK1 | |
| SCHEMBL12856233 | 0.81 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTSIRT6CYP1A2 | |
| SCHEMBL12312068 | 0.81 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTSIRT6MAPK1 | |
| SCHEMBL12862130 | 0.80 | SIRT6 (0.75) | ALDH1A1LMNAMAPTSIRT6MAPK1 | |
| SCHEMBL12312000 | 0.79 | DPP4 (0.45) | ALDH1A1LMNAMAPTEGFRSUV39H2 | |
| SCHEMBL13380460 | 0.78 | SUV39H2 (0.44) | ALDH1A1LMNAMAPTEGFRSUV39H2 | |
| SCHEMBL16431871 | 0.78 | SUV39H2 (0.47) | ALDH1A1LMNAMAPTEGFRSUV39H2 | |
| SCHEMBL517295 | 0.78 | ALDH1A1 (0.70) | ALDH1A1LMNAMAPTSIRT6MAPK1 | |
| SCHEMBL517280 | 0.76 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTSIRT6MAPK1 | |
| SCHEMBL517279 | 0.76 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTSIRT6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-A1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders. | Novartis AG (CH) | 2011-01-19 | — | — | EP | disclosed |