Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | PTAFR | P25105 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522007 | 0.81 | PTAFR (0.44) | HTR2AMAPTKDM4EHTR2CPTAFR | |
| SCHEMBL5661115 | 0.80 | HTR2A (0.36) | HTR2AGAAMAPTKDM4ETSHR | |
| SCHEMBL13850102 | 0.79 | PTGDR2 (0.39) | HTR2AKDM4EHTR2CADRA1ACYP3A4 | |
| SCHEMBL148897 | 0.77 | MAPT (0.47) | GAAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL7938441 | 0.76 | KDM4E (0.46) | HTR2AGAAMAPTKDM4ETSHR | |
| SCHEMBL2570589 | 0.76 | MAPT (0.48) | HTR2AGAAMAPTKDM4ETSHR | |
| SCHEMBL7748976 | 0.73 | KDM4E (0.37) | HTR2AMAPTKDM4ETSHRALDH1A1 | |
| SCHEMBL30868519 | 0.73 | HTR2A (0.54) | HTR2AGAAMAPTKDM4ETSHR | |
| SCHEMBL10492495 | 0.72 | TDO2 (0.38) | HTR2AMAPTKDM4ETSHRADRA1A | |
| SCHEMBL11819421 | 0.71 | HTR2A (0.53) | HTR2AGAAMAPTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309560-B1 | Pyridine derivatives as inhibitors of p38 | VERTEX PHARMA (US) | 2012-10-03 | — | — | EP | disclosed |
| EP-1077943-B1 | HETEROCYCLIC INHIBITORS OF P38 | VERTEX PHARMA (US) | 2008-12-17 | — | — | EP | disclosed |