Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12964681 | 0.86 | P2RX7 (0.58) | RXRAGRIN1GRIN2BNOTUMP2RX7 | |
| SCHEMBL12766882 | 0.83 | RXRA (0.53) | RXRAGRIN1GRIN2BNOTUMFLT1 | |
| SCHEMBL12964509 | 0.78 | KDM1A (0.48) | NOTUMP2RX7MAPT | |
| SCHEMBL1525984 | 0.76 | RXRA (0.45) | RXRAGRIN1GRIN2BFLT1KDR | |
| SCHEMBL19514072 | 0.75 | RXRA (0.64) | RXRAGRIN1GRIN2BNOTUMP2RX7 | |
| SCHEMBL19211427 | 0.75 | NOTUM (0.67) | RXRAGRIN1GRIN2BNOTUMP2RX7 | |
| SCHEMBL21611991 | 0.72 | CYP3A4 (0.78) | RXRAGRIN1GRIN2BCYP3A4CYP2C19 | |
| SCHEMBL19219450 | 0.70 | RXRA (1.00) | RXRAGRIN1GRIN2B | |
| SCHEMBL18028308 | 0.70 | RXRA (0.57) | RXRAGRIN1GRIN2BNOTUMFLT1 | |
| SCHEMBL1499552 | 0.70 | NOTUM (0.49) | RXRAGRIN1GRIN2BNOTUMKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131656-A2 | COMPOUNDS FOR USE AS THERAPEUTIC AGENTS AFFECTING P53 EXPRESSION AND/OR ACTIVITY | SOCIÉTÉ SPLICOS (FR) | 2012-10-04 | — | — | WO | disclosed |
| EP-2505198-A1 | Compounds for use as therapeutic agents affecting p53 expression and/or activity | Société Splicos (FR) | 2012-10-03 | — | — | EP | disclosed |