Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.60 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 5/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12965720 | 0.80 | AXL (0.46) | TNIKMAP3K11AXLCDK2FLT3 | |
| SCHEMBL14409689 | 0.74 | LMNA (0.59) | — | |
| SCHEMBL20635688 | 0.72 | TNIK (0.52) | TNIKMAP3K11FGFR1FLT3ABL1 | |
| SCHEMBL18921934 | 0.71 | AXL (0.45) | TNIKMAP3K11AXLFGFR1CDK2 | |
| SCHEMBL12821734 | 0.71 | PDE1B (0.49) | MAP3K11AXLFGFR1CDK2FLT3 | |
| SCHEMBL3338493 | 0.69 | LMNA (0.62) | — | |
| SCHEMBL25550759 | 0.69 | AXL (0.58) | AXLFGFR1CDK6JAK2 | |
| SCHEMBL26640349 | 0.68 | AXL (0.51) | AXLFGFR1CDK2JAK2 | |
| SCHEMBL15154791 | 0.68 | MAP3K11 (0.80) | TNIKMAP3K11SYKCDK2FLT3 | |
| SCHEMBL2981047 | 0.68 | LMNA (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012135631-A1 | SUBSTITUTED 5-(PYRAZIN-2-YL)-1H-PYRAZOLO [3, 4-B] PYRIDINE AND PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ARRIEN PHARMAEUTICALS LLC (US) | 2012-10-04 | — | — | WO | disclosed |