Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12821734 | 0.81 | PDE1B (0.49) | AXLMAP3K11ABL1CDK2FLT3 | |
| SCHEMBL18921922 | 0.78 | NMT1 (0.48) | TNIKMAP3K11NMT1 | |
| SCHEMBL12965720 | 0.78 | AXL (0.46) | AXLTNIKMAP3K11IKBKBCHUK | |
| SCHEMBL12965705 | 0.71 | TNIK (0.60) | AXLTNIKMAP3K11IKBKBCHUK | |
| SCHEMBL14409689 | 0.70 | LMNA (0.59) | — | |
| SCHEMBL14887083 | 0.70 | LMNA (0.42) | MAP3K11CDK2NMT1JAK2JAK3 | |
| SCHEMBL18921930 | 0.65 | HTR6 (0.41) | AXLWEE1 | |
| SCHEMBL12813489 | 0.64 | AXL (0.77) | AXLJAK2 | |
| SCHEMBL3338493 | 0.63 | LMNA (0.62) | — | |
| SCHEMBL5469332 | 0.62 | FLT1 (0.58) | AXLTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962382-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-05-08 | — | — | US | disclosed |
| US-9669028-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2017-06-06 | — | — | US | disclosed |