Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767156 | 0.88 | SNCA (0.46) | SNCANPC1RAB9AGAAMAPT | |
| SCHEMBL12967265 | 0.88 | HDAC6 (0.39) | RAB9ASMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL15763557 | 0.87 | SIGMAR1 (0.46) | SNCANPC1RAB9AGAAMAPT | |
| SCHEMBL12964620 | 0.87 | MAPT (0.49) | NPC1GAAMAPTSMN1; SMN2HPGD | |
| SCHEMBL12964542 | 0.86 | NPC1 (0.51) | NPC1RAB9AGAAMAPTSMN1; SMN2 | |
| SCHEMBL12767155 | 0.86 | SNCA (0.49) | SNCANPC1RAB9AAPPSMN1; SMN2 | |
| SCHEMBL12967414 | 0.77 | APP (0.37) | NPC1RAB9AGAAMAPTAPP | |
| SCHEMBL15878029 | 0.76 | SNCA (0.53) | SNCANPC1RAB9AGAAMAPT | |
| SCHEMBL12767150 | 0.76 | SNCA (0.53) | SNCANPC1RAB9AGAAMAPT | |
| SCHEMBL15894878 | 0.76 | GAA (0.52) | NPC1RAB9AGAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131656-A2 | COMPOUNDS FOR USE AS THERAPEUTIC AGENTS AFFECTING P53 EXPRESSION AND/OR ACTIVITY | SOCIÉTÉ SPLICOS (FR) | 2012-10-04 | — | — | WO | disclosed |