Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499435 | 0.88 | HDAC6 (0.41) | HDAC6KMT2AMEN1AGTR1RAB9A | |
| SCHEMBL1499432 | 0.88 | HDAC6 (0.41) | HDAC6KMT2AMEN1AGTR1RAB9A | |
| SCHEMBL12966950 | 0.88 | SNCA (0.48) | HDAC6KMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL12766948 | 0.85 | NAMPT (0.40) | HDAC6KMT2AMEN1AGTR1RAB9A | |
| SCHEMBL12964620 | 0.79 | MAPT (0.49) | KMT2AMEN1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL1499537 | 0.78 | NAMPT (0.40) | KMT2AMEN1AGTR1RAB9ASMN1; SMN2 | |
| SCHEMBL1499538 | 0.78 | NAMPT (0.40) | KMT2AMEN1AGTR1RAB9ASMN1; SMN2 | |
| SCHEMBL1499689 | 0.78 | HDAC3 (0.46) | HDAC6KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1499693 | 0.78 | HDAC3 (0.46) | HDAC6KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL12967273 | 0.76 | KDM4E (0.33) | HDAC6RAB9AALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131656-A2 | COMPOUNDS FOR USE AS THERAPEUTIC AGENTS AFFECTING P53 EXPRESSION AND/OR ACTIVITY | SOCIÉTÉ SPLICOS (FR) | 2012-10-04 | — | — | WO | disclosed |