Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12870220 | 0.85 | MET (0.51) | MET | |
| SCHEMBL12858128 | 0.85 | MET (0.39) | METMEN1KMT2A | |
| SCHEMBL1151066 | 0.80 | MET (0.62) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL12870219 | 0.75 | MET (0.51) | MET | |
| SCHEMBL1151835 | 0.75 | MET (0.51) | METMEN1KMT2A | |
| SCHEMBL12857947 | 0.75 | MET (0.39) | METMEN1KMT2A | |
| SCHEMBL12870218 | 0.73 | MET (0.48) | MET | |
| SCHEMBL12857965 | 0.73 | MET (0.37) | MET | |
| SCHEMBL1151415 | 0.72 | MET (0.70) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL13284451 | 0.71 | MET (0.59) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280962-B1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-10-03 | — | — | EP | disclosed |