Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ACE | P12821 | 4/20 | 0.56 |
| ▸ | DPP4 | P27487 | 2/20 | 0.52 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.52 |
| ▸ | PREP | P48147 | 3/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18620591 | 0.89 | ACE (0.64) | ALDH1A1CYP3A4TSHRACEFKBP1A | |
| SCHEMBL7303514 | 0.89 | ACE (0.64) | ALDH1A1CYP3A4TSHRACEFKBP1A | |
| SCHEMBL2499034 | 0.87 | ALDH1A1 (0.61) | ALDH1A1CYP3A4TSHRACEFKBP1A | |
| SCHEMBL38652097 | 0.87 | CMA1 (0.56) | ACEFKBP1AITGB3ITGA2BCMA1 | |
| SCHEMBL29880727 | 0.86 | ALDH1A1 (0.60) | ALDH1A1CYP3A4TSHRACEDPP4 | |
| SCHEMBL8198229 | 0.85 | PREP (0.70) | ALDH1A1CYP3A4TSHRACEFKBP1A | |
| SCHEMBL22209424 | 0.85 | PREP (0.70) | ALDH1A1CYP3A4TSHRACEFKBP1A | |
| SCHEMBL30051892 | 0.85 | PREP (0.70) | ALDH1A1CYP3A4TSHRACEFKBP1A | |
| SCHEMBL7305929 | 0.85 | PREP (0.70) | ALDH1A1CYP3A4TSHRACEFKBP1A | |
| SCHEMBL31473142 | 0.85 | ALDH1A1 (0.58) | ALDH1A1CYP3A4TSHRACEDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655399-B1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2017-09-27 | — | — | EP | disclosed |
| US-8497245-B2 | Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors IIa and Xa | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-07-30 | — | — | US | disclosed |
| US-20120252743-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252743-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | F2, F12, SERPINC1 | ALDH1A1 3812/4885CYP3A4 746/4885TSHR 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.