Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468516 | 0.89 | NPC1 (0.61) | APPALDH1A1ALDH1A3KDM4ENPC1 | |
| SCHEMBL12970538 | 0.85 | RAB9A (0.59) | APPALDH1A1ALDH1A3CLK1DYRK1A | |
| SCHEMBL12970091 | 0.85 | KDM4E (0.60) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL3500247 | 0.83 | NPC1 (0.56) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL2426213 | 0.82 | APP (0.62) | APPALDH1A1ALDH1A3CYP11B1CYP11B2 | |
| SCHEMBL12970268 | 0.81 | RAB9A (0.63) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL12970585 | 0.81 | KDM4E (0.65) | ALDH1A1KDM4ENPC1RAB9APOLB | |
| SCHEMBL4098270 | 0.80 | KDM4E (0.64) | ALDH1A1KDM4ENPC1RAB9APOLB | |
| SCHEMBL21727398 | 0.79 | APP (0.65) | APPALDH1A1ALDH1A3CYP11B1CYP11B2 | |
| SCHEMBL2128899 | 0.79 | ALDH1A1 (0.72) | APPALDH1A1ALDH1A3CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012133607-A1 | PYRAZOLE COMPOUND | アステラス製薬株式会社 (JP) | 2012-10-04 | — | — | WO | disclosed |