Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12969929 | 0.81 | PDE10A (0.42) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL12970150 | 0.78 | PDE10A (0.58) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL12970321 | 0.77 | SLC6A2 (0.45) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL25187676 | 0.76 | PDE10A (0.42) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL30123521 | 0.76 | PDE10A (0.42) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL12970179 | 0.76 | PDE10A (0.47) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL12970447 | 0.76 | PDE10A (0.46) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL12970545 | 0.75 | PDE10A (0.36) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL23070575 | 0.74 | DGAT1 (0.45) | PDE10AALDH1A1LMNAHTTDGAT1 | |
| SCHEMBL12970073 | 0.74 | PDE10A (0.40) | PDE10APDE4APDE4BPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012133607-A1 | PYRAZOLE COMPOUND | アステラス製薬株式会社 (JP) | 2012-10-04 | — | — | WO | disclosed |