Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | HTR6 | P50406 | 10/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12970302 | 0.90 | HTR6 (0.43) | SLC6A2SLC6A4SLC6A3HTR1AHTR6 | |
| SCHEMBL12970405 | 0.86 | PDK1 (0.38) | PDE4APDE4BPDE3BPDE3APDE10A | |
| SCHEMBL12970545 | 0.84 | PDE10A (0.36) | PDE4APDE4BPDE3BPDE3APDE10A | |
| SCHEMBL12969929 | 0.81 | PDE10A (0.42) | PDE4APDE4BPDE3BPDE3APDE10A | |
| SCHEMBL12969915 | 0.80 | PDE10A (0.44) | PDE4APDE4BPDE3BPDE10AGABRA1 | |
| SCHEMBL12970150 | 0.78 | PDE10A (0.58) | PDE4APDE4BPDE3BPDE3APDE10A | |
| SCHEMBL12970586 | 0.77 | PDE10A (0.38) | PDE4APDE4BPDE3BPDE3APDE10A | |
| SCHEMBL12970293 | 0.76 | PRMT5 (0.42) | PDE10APDK1PDK2PDK3PDK4 | |
| SCHEMBL25187676 | 0.76 | PDE10A (0.42) | PDE4APDE4BPDE3BPDE3APDE10A | |
| SCHEMBL12970179 | 0.76 | PDE10A (0.47) | PDE4APDE4BPDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012133607-A1 | PYRAZOLE COMPOUND | アステラス製薬株式会社 (JP) | 2012-10-04 | — | — | WO | disclosed |