Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 17/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 16/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 16/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 16/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12979515 | 0.96 | PIK3CA (0.52) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12979256 | 0.87 | MAPK1 (0.49) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12979793 | 0.87 | MAPK1 (0.48) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12979641 | 0.86 | MAPK1 (0.51) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12979558 | 0.86 | MAPK1 (0.46) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12978890 | 0.85 | PIK3CA (0.46) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL13191842 | 0.85 | PIK3CA (0.58) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12978887 | 0.84 | PIK3CA (0.58) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12979100 | 0.83 | MAPK1 (0.48) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL12979485 | 0.83 | PIK3CA (0.44) | PIK3CAMAPK1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694068-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | Æterna Zentaris GmbH (DE) | 2014-02-12 | — | — | EP | claimed |
| CN-103501788-A | Pyridopyrazine derivatives and their use | AETERNA ZENTARIS GMBH | 2014-01-08 | — | — | CN | claimed |
| WO-2012136694-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ÆTERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | WO | claimed |
| US-20120259151-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | AETERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | US | claimed |
| US-8912189-B2 | Pyridopyrazine derivatives and their use | AETERNA ZENTARIS GMBH (DE) | 2014-12-16 | — | — | US | disclosed |
| US-8912189-B2 | Pyridopyrazine derivatives and their use | AETERNA ZENTARIS GMBH (DE) | 2014-12-16 | — | — | US | disclosed |
| US-8912189-B2 | Pyridopyrazine derivatives and their use | AETERNA ZENTARIS GMBH (DE) | 2014-12-16 | — | — | US | disclosed |
| EP-2694068-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | Æterna Zentaris GmbH (DE) | 2014-02-12 | — | — | EP | disclosed |
| CN-103501788-A | Pyridopyrazine derivatives and their use | AETERNA ZENTARIS GMBH | 2014-01-08 | — | — | CN | disclosed |
| US-20120259151-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | AETERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | US | disclosed |
| WO-2012136694-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ÆTERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |
| WO-2012136694-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ÆTERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |
| US-20120259151-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | AETERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | US | disclosed |
| US-20120259151-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | AETERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120259151-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | PLPBP, PDXK, MAP4K2 | PIK3CA 866/4885MAPK1 58/4885MAPK8 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.