Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12980863 | 0.84 | SMN1; SMN2 (0.67) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL16602332 | 0.84 | MAPT (0.82) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL12963451 | 0.83 | RAB9A (0.69) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL12980741 | 0.83 | SMN1; SMN2 (0.65) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL12980452 | 0.82 | MAPT (0.65) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL1074520 | 0.81 | TP53 (0.80) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL12980557 | 0.80 | MAPT (0.66) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL12963207 | 0.78 | SMN1; SMN2 (0.78) | MAPTTP53RXFP1POLBRAB9A | |
| SCHEMBL4910770 | 0.77 | RAB9A (1.00) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL12553629 | 0.77 | MEN1 (0.74) | MAPTRAB9ASMN1; SMN2THRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150150852-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2015-06-04 | — | — | US | disclosed |
| US-8993604-B2 | Treatment and prevention of dengue virus infections | SIGA TECHNOLOGIES, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150150852-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | HAVCR2, TTPA, CHIA | MAPT 118/4885TP53 2739/4885RXFP1 4348/4885 |
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | HAVCR2, TTPA, CHIA | MAPT 118/4885TP53 2739/4885RXFP1 4348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.