Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.80 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621707 | 0.89 | PARP1 (1.00) | PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL18614370 | 0.88 | PARP1 (0.98) | PARP1PARP2 | |
| SCHEMBL1298158 | 0.82 | PARP1 (0.80) | PARP1PARP2 | |
| SCHEMBL6872050 | 0.79 | PARP1 (0.70) | PARP1PARP2 | |
| SCHEMBL5620711 | 0.78 | PARP1 (0.79) | PARP1PARP2 | |
| SCHEMBL7444261 | 0.76 | PARP1 (0.57) | PARP1PARP2 | |
| SCHEMBL630129 | 0.73 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL2243349 | 0.73 | PARP1 (0.55) | PARP1KDM4E | |
| SCHEMBL630259 | 0.72 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL633643 | 0.72 | PARP1 (1.00) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871946-B2 | Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2386553-A1 | BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES | Shanghai Jiao Tong University (CN) | 2011-11-16 | — | — | EP | disclosed |
| US-20110269766-A1 | Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2011-11-03 | — | — | US | disclosed |
| US-20110253582-A1 | MOLDABLE ARTICLES, METHOD OF MAKING SAME AND METHOD OF MOLDING | 3M INNOVATIVE PROPERTIES COMPANY | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269766-A1 | Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, PAICS, HDAC6 | PARP1 167/4885PARP2 373/4885KDM4E 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.