Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 1.00 |
| ▸ | RAB9A | P51151 | 13/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.96 |
| ▸ | MAPT | P10636 | 8/20 | 0.96 |
| ▸ | HPGD | P15428 | 5/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.96 |
| ▸ | TP53 | P04637 | 4/20 | 0.96 |
| ▸ | PKM | P14618 | 3/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.96 |
| ▸ | GMNN | O75496 | 1/20 | 0.96 |
| ▸ | THPO | P40225 | 1/20 | 0.96 |
| ▸ | BLM | P54132 | 1/20 | 0.96 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.96 |
| ▸ | AR | P10275 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL483422 | 0.98 | KDM4E (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL29693306 | 0.98 | KDM4E (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL2487558 | 0.98 | KDM4E (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12402712 | 0.90 | NPC1 (0.81) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12112870 | 0.89 | RAB9A (0.80) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL31571831 | 0.83 | RAB9A (0.71) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL706884 | 0.83 | RAB9A (0.71) | NPC1RAB9AMEN1KMT2AKDM4E | |
| 2-Phenylquinoline SCHEMBL29399739 | 0.83 | RAB9A (0.73) | NPC1RAB9AMEN1KMT2AKDM4E | |
| 2-Phenylquinoline SCHEMBL44999 | 0.83 | RAB9A (0.73) | NPC1RAB9AMEN1KMT2AKDM4E | |
| 2-Phenylquinoline SCHEMBL6858671 | 0.81 | RAB9A (0.70) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640703-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | GE Healthcare UK Limited (GB) | 2013-09-25 | — | — | EP | claimed |
| US-20130236395-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | GE HEALTHCARE LIMITED (GB) | 2013-09-12 | — | — | US | claimed |
| CN-103298789-A | Heterocyclic compounds as imaging probes of tau pathology | GE HEALTHCARE LTD | 2013-09-11 | — | — | CN | claimed |
| WO-2012067863-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | GE HEALTHCARE LIMITED (GB) | 2012-05-24 | — | — | WO | claimed |
| US-7118730-B2 | Quinoline derivative as diagnostic probe for disease with tau protein accumulation | BF RESEARCH INSTITUTE, INC. (JP) | 2006-10-10 | — | — | US | claimed |
| US-20250340547-A1 | NOVEL COMPOUNDS FOR IMAGING TAU PROTEINS THAT ACCUMULATE IN THE BRAIN | NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY (JP) | 2025-11-06 | — | — | US | disclosed |
| US-12195454-B2 | Compounds for imaging tau proteins that accumulate in the brain | NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY (JP) | 2025-01-14 | — | — | US | disclosed |
| CN-117987155-A | Low-temperature curing liquid crystal aligning agent, liquid crystal aligning film, preparation method of liquid crystal aligning film and liquid crystal display element | 深圳市道尔顿电子材料股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| US-20240083893-A1 | COMPOUNDS FOR IMAGING TAU PROTEINS THAT ACCUMULATE IN THE BRAIN | NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY (JP) | 2024-03-14 | — | — | US | disclosed |
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230183209-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2023-06-15 | — | — | US | disclosed |
| US-11667628-B2 | Compounds for imaging tau proteins that accumulate in brain | NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY (JP) | 2023-06-06 | — | — | US | disclosed |
| WO-2011119565-A1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011115513-A2 | A CYTOSINE ANALOGUE, A METHOD OF PREPARATION OF A CYTOSINE ANALOGUE, A DNA METHYLTRANSFERASE 1 INHIBITOR, A METHOD FOR DNA METHYLATION INHIBITION, THE USE OF THE ANALOGUE IN THE TREATMENT OF DISEASES ASSOCIATED WITH DEVIATIONS FROM NORMAL DNA METHYLATION | INSTYTUT CHEMII BIOORGANICZNEJ PAN (PL) | 2011-09-22 | — | — | WO | disclosed |
| US-7118730-B2 | Quinoline derivative as diagnostic probe for disease with tau protein accumulation | BF RESEARCH INSTITUTE, INC. (JP) | 2006-10-10 | — | — | US | disclosed |
| US-20050260126-A1 | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein | BF RESEARCH INSTITUTE (JP) | 2005-11-24 | — | — | US | disclosed |
| EP-1574500-A1 | QUINOLINE DERIVATIVE AS DIAGNOSTIC PROBE FOR DISEASE WITH TAU PROTEIN ACCUMULATION | BF Research Institute, Inc. (JP) | 2005-09-14 | — | — | EP | disclosed |
| US-20050009865-A1 | Quinoline derivative as diagnostic probe for disease with tau protein accumulation | BF RESEARCH INSTITUTE, INC. (JP) | 2005-01-13 | — | — | US | disclosed |
| EP-0168812-A1 | 4-Amino-2-phenyl quinolines, methods and intermediates for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-01-22 | — | — | EP | disclosed |
| EP-0087709-A1 | N,N',N\"-triaryl-1,2,3-triaminopropane derivatives, process for their preparation and their use as intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183209-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | NPC1 3571/4885RAB9A 3202/4885MEN1 727/4885 |
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | NPC1 2550/4885RAB9A 1429/4885MEN1 1944/4885 |
| US-20240083893-A1 | COMPOUNDS FOR IMAGING TAU PROTEINS THAT ACCUMULATE IN THE BRAIN | MAPT, FABP7, HTT | NPC1 1911/4885RAB9A 1120/4885MEN1 4010/4885 |
| US-12195454-B2 | Compounds for imaging tau proteins that accumulate in the brain | MAPT, FABP7, HTT | NPC1 1911/4885RAB9A 1120/4885MEN1 4010/4885 |
| US-20050009865-A1 | Quinoline derivative as diagnostic probe for disease with tau protein accumulation | MAPT, APP, PSEN1 | NPC1 332/4885RAB9A 2676/4885MEN1 1854/4885 |
| US-20050260126-A1 | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein | PRNP, PRPH, PCNP | NPC1 147/4885RAB9A 1787/4885MEN1 3565/4885 |
| US-11667628-B2 | Compounds for imaging tau proteins that accumulate in brain | MAPT, FABP7, HTT | NPC1 1841/4885RAB9A 1119/4885MEN1 3842/4885 |
| US-20250340547-A1 | NOVEL COMPOUNDS FOR IMAGING TAU PROTEINS THAT ACCUMULATE IN THE BRAIN | MAPT, FABP7, HTT | NPC1 2035/4885RAB9A 948/4885MEN1 4288/4885 |
| US-20130236395-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | MAPT, PSEN1, PSEN2 | NPC1 127/4885RAB9A 1703/4885MEN1 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.