Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12103416 | 0.95 | MAPT (0.43) | MAPTLMNAPOLBGAASYK | |
| SCHEMBL12106816 | 0.83 | MAPT (0.41) | MAPTLMNASYKZAP70MAPK1 | |
| SCHEMBL1298125 | 0.82 | MAPK1 (0.45) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL1939342 | 0.81 | SYK (0.55) | MAPTLMNAPOLBSYKMAPK1 | |
| SCHEMBL12103792 | 0.80 | MAPK1 (0.43) | MAPTLMNAPOLBSYKZAP70 | |
| SCHEMBL15264614 | 0.79 | MAPT (0.52) | MAPTLMNAGAASYKMAPK1 | |
| SCHEMBL19245971 | 0.79 | MAPK1 (0.44) | MAPTLMNAGAASYKMAPK1 | |
| SCHEMBL12103419 | 0.79 | MAPT (0.39) | MAPTLMNAPOLBSYKZAP70 | |
| SCHEMBL18352017 | 0.78 | SYK (0.45) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL1298740 | 0.77 | TP53 (0.56) | MAPTLMNAPOLBSYKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | disclosed |
| EP-2493313-A1 | KINASE INHIBITORS | Genosco (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20110269739-A1 | KINASE INHIBITORS | OSCOTEC, INC. (KR) | 2011-11-03 | — | — | US | disclosed |
| US-20110269739-A1 | KINASE INHIBITORS | OSCOTEC, INC. (KR) | 2011-11-03 | — | — | US | disclosed |
| WO-2011053861-A1 | KINASE INHIBITORS | GENOSCO (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011053861-A1 | KINASE INHIBITORS | GENOSCO (US) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269739-A1 | KINASE INHIBITORS | JAK1, LCK, MAP3K20 | MAPT 1060/4885LMNA 3917/4885POLB 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.