Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1988610 | 0.90 | LMNA (0.48) | SYKMAPK1HTTMAPTL3MBTL1 | |
| SCHEMBL16964287 | 0.86 | SYK (0.51) | SYKMAPK1HTTMAPTL3MBTL1 | |
| SCHEMBL1298740 | 0.86 | TP53 (0.56) | SYKMAPK1HTTMAPTL3MBTL1 | |
| SCHEMBL1939779 | 0.85 | LMNA (0.53) | SYKMAPK1HTTMAPTL3MBTL1 | |
| SCHEMBL1949965 | 0.84 | LMNA (0.49) | SYKTP53LMNARXFP1SMN1; SMN2 | |
| SCHEMBL18351982 | 0.83 | SYK (0.48) | SYKMAPK1HTTMAPTL3MBTL1 | |
| SCHEMBL12103416 | 0.83 | MAPT (0.43) | SYKMAPK1HTTMAPTTP53 | |
| SCHEMBL19245828 | 0.81 | ALOX5 (0.51) | SYKMAPK1HTTMAPTLMNA | |
| SCHEMBL12103792 | 0.81 | MAPK1 (0.43) | SYKMAPK1HTTMAPTL3MBTL1 | |
| SCHEMBL1298459 | 0.81 | MAPT (0.44) | SYKMAPK1HTTMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900639-B1 | BICYCLIC DIHYDROPYRIDONE KINASE INHIBITORS | PORTOLA PHARM INC (US) | 2017-08-16 | — | — | EP | disclosed |
| EP-2900639-B1 | BICYCLIC DIHYDROPYRIDONE KINASE INHIBITORS | PORTOLA PHARM INC (US) | 2017-08-16 | — | — | EP | disclosed |
| US-9533986-B2 | Bicyclic dihydropyridone kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2017-01-03 | — | — | US | disclosed |
| US-9533986-B2 | Bicyclic dihydropyridone kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2017-01-03 | — | — | US | disclosed |
| US-20150266871-A1 | BICYCLIC DIHYDROPYRIDONE KINASE INHIBITORS | ALEXION PHARMACEUTICALS, INC. | 2015-09-24 | — | — | US | disclosed |
| EP-2900639-A1 | BICYCLIC DIHYDROPYRIDONE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2330909-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2013-09-18 | — | — | EP | disclosed |
| US-8383635-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383635-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383635-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2330909-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20110136838-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-06-09 | — | — | US | disclosed |
| US-20110136838-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-06-09 | — | — | US | disclosed |
| US-20110136838-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-06-09 | — | — | US | disclosed |
| WO-2010019637-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010019637-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266871-A1 | BICYCLIC DIHYDROPYRIDONE KINASE INHIBITORS | SYK, JAK2, ZAP70 | SYK 1/4885MAPK1 512/4885HTT 2725/4885 |
| US-20110136838-A1 | CHEMICAL COMPOUNDS | PDK1, PDK4, PDK3 | SYK 1481/4885MAPK1 201/4885HTT 2920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.