Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FOS | P01100 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18351993 | 0.87 | SYK (0.42) | SYKJAK3JAK2JAK1AURKA | |
| SCHEMBL18352002 | 0.83 | MAPT (0.40) | SYKJAK3JAK2JAK1AURKA | |
| SCHEMBL28496543 | 0.83 | SYK (0.67) | SYKJAK3JAK2JAK1AURKA | |
| SCHEMBL1298459 | 0.78 | MAPT (0.44) | SYKMAPTLMNAMAPK1HTT | |
| SCHEMBL1939342 | 0.77 | SYK (0.55) | SYKMAPTLMNAMAPK1HTT | |
| SCHEMBL1298125 | 0.76 | MAPK1 (0.45) | SYKMAPTLMNAMAPK1HTT | |
| SCHEMBL15264614 | 0.75 | MAPT (0.52) | SYKMAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL12103416 | 0.75 | MAPT (0.43) | SYKMAPTLMNAMAPK1HTT | |
| SCHEMBL17069451 | 0.75 | ALK (0.44) | SYKJAK3JAK2JAK1AURKB | |
| SCHEMBL18352112 | 0.75 | SYK (0.45) | SYKJAK3JAK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533986-B2 | Bicyclic dihydropyridone kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2017-01-03 | — | — | US | disclosed |