Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1063578 | 0.99 | LMNA (0.52) | HTR3AHTR3EHTR3BADRB1DRD2 | |
| SCHEMBL1026306 | 0.94 | CYP2C19 (0.57) | HTR3AHTR3EHTR3BADRB1DRD2 | |
| Hydrochloric Acid SCHEMBL30069211 | 0.93 | LMNA (0.58) | HTR3AHTR3EHTR3BADRB1DRD2 | |
| Hydrochloric Acid SCHEMBL30069213 | 0.93 | LMNA (0.58) | HTR3AHTR3EHTR3BADRB1DRD2 | |
| Hydrochloric Acid SCHEMBL26600676 | 0.93 | LMNA (0.58) | HTR3AHTR3EHTR3BADRB1DRD2 | |
| Hydrochloric Acid SCHEMBL1969103 | 0.93 | LMNA (0.58) | HTR3AHTR3EHTR3BADRB1DRD2 | |
| SCHEMBL29086088 | 0.86 | SLC2A1 (0.52) | DRD2CYP2C19DRD3HTR7MAPT | |
| SCHEMBL30585959 | 0.86 | SLC2A1 (0.52) | DRD2CYP2C19DRD3HTR7MAPT | |
| SCHEMBL27815937 | 0.85 | CYP1A2 (0.51) | DRD2CYP2C19DRD3HTR7LMNA | |
| SCHEMBL14818765 | 0.81 | EPHX2 (0.54) | ADRB1CHRNB2CHRNA4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349273-B1 | MODULATORS OF CXCR7 | CHEMOCENTRYX INC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8853202-B2 | Modulators of CXCR7 | CHEMOCENTRYX, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-8288373-B2 | Modulators of CXCR7 | CHEMOCENTRYX, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20100311712-A1 | MODULATORS OF CXCR7 | CHEMOCENTRYX, INC. (US) | 2010-12-09 | — | — | US | disclosed |
| US-20100150831-A1 | MODULATORS OF CXCR7 | CHEMOCENTRYX, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| WO-2010054006-A1 | MODULATORS OF CXCR7 | CHEMOCENTRYX, INC. (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311712-A1 | MODULATORS OF CXCR7 | CXCR1, CXCR5, CCR7 | HTR3A 862/4885HTR3E 836/4885HTR3B 524/4885 |
| US-20100150831-A1 | MODULATORS OF CXCR7 | CXCR1, CXCR5, CCR7 | HTR3A 862/4885HTR3E 836/4885HTR3B 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.