Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 8/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 8/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 7/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL350704 | 0.97 | SLC7A5 (0.53) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL350703 | 0.97 | SLC7A5 (0.53) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL5284864 | 0.79 | SLC7A5 (0.57) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL29524472 | 0.79 | SLC7A5 (0.57) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL1007447 | 0.78 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL600021 | 0.78 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL468084 | 0.78 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL25933046 | 0.78 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL29957453 | 0.78 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3USP2 | |
| SCHEMBL14601662 | 0.76 | SLC7A5 (0.53) | SLC7A5SLC1A2SLC1A1SLC1A3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9410968-B2 | Biomarkers for acute kidney injury | UNIVERSITEIT GENT (BE) | 2016-08-09 | — | — | US | disclosed |
| EP-2694974-B1 | BIOMARKERS FOR ACUTE KIDNEY INJURY | UNIV GENT (BE) | 2015-10-21 | — | — | EP | disclosed |
| EP-2694974-A1 | BIOMARKERS FOR ACUTE KIDNEY INJURY | Universiteit Gent (BE) | 2014-02-12 | — | — | EP | disclosed |
| US-20140017702-A1 | BIOMARKERS FOR ACUTE KIDNEY INJURY | UNIVERSITEIT GENT (BE) | 2014-01-16 | — | — | US | disclosed |
| WO-2012136548-A1 | BIOMARKERS FOR ACUTE KIDNEY INJURY | UNIVERSITEIT GENT (BE) | 2012-10-11 | — | — | WO | disclosed |