Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068603 | 0.94 | SMN1; SMN2 (0.61) | SMN1; SMN2HPGDNPC1ALDH1A1LMNA | |
| SCHEMBL11036233 | 0.94 | SMN1; SMN2 (0.61) | SMN1; SMN2HPGDNPC1ALDH1A1LMNA | |
| SCHEMBL11035964 | 0.86 | EPHX1 (0.68) | ALDH1A1EPHX2EPHX1 | |
| SCHEMBL11034979 | 0.86 | EPHX1 (0.68) | ALDH1A1EPHX2EPHX1 | |
| SCHEMBL2730689 | 0.86 | SMN1; SMN2 (0.85) | SMN1; SMN2HPGDNPC1ALDH1A1LMNA | |
| SCHEMBL17715557 | 0.85 | TPSAB1 (0.54) | SMN1; SMN2HPGDCYP2C9TSHRMEN1 | |
| SCHEMBL3421197 | 0.85 | EPHX2 (0.73) | SMN1; SMN2HPGDALDH1A1TSHREPHX2 | |
| SCHEMBL20649314 | 0.83 | SMN1; SMN2 (0.69) | SMN1; SMN2HPGDNPC1ALDH1A1LMNA | |
| SCHEMBL11366053 | 0.82 | EPHX1 (0.61) | ALDH1A1EPHX2EPHX1 | |
| SCHEMBL11360702 | 0.82 | EPHX1 (0.61) | ALDH1A1EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258677-A2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-12-08 | — | — | EP | disclosed |