Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19357879 | 0.85 | CKS1B (0.48) | MTORC5AR1PARP1TNKS2PARP2 | |
| SCHEMBL13195154 | 0.79 | PIK3R1 (0.52) | MTOR | |
| SCHEMBL15769161 | 0.79 | PIK3R1 (0.52) | MTOR | |
| SCHEMBL12988096 | 0.78 | CA12 (0.48) | ALDH1A1MAPTMTORC5AR1L3MBTL1 | |
| SCHEMBL1832431 | 0.77 | PARP1 (0.46) | MAPTMTORPARP1TNKS2PARP2 | |
| SCHEMBL27083693 | 0.76 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTMTORC5AR1 | |
| SCHEMBL30458208 | 0.76 | MAPT (0.51) | ALDH1A1LMNAMAPTMTORC5AR1 | |
| SCHEMBL19358103 | 0.75 | KCNK3 (0.40) | C5AR1PARP1TNKS2PARP2KCNK3 | |
| SCHEMBL443240 | 0.75 | POLB (0.40) | ALDH1A1MAPTMTORC5AR1PARP1 | |
| SCHEMBL27083701 | 0.75 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTMTORESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163023-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2014-06-12 | — | — | US | disclosed |
| US-20140163023-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2014-06-12 | — | — | US | disclosed |
| US-20140163023-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2014-06-12 | — | — | US | disclosed |
| EP-2694511-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Cellzome Limited (GB) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012136622-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-11 | — | — | WO | disclosed |
| WO-2012136622-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163023-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | MTOR, RICTOR, RPTOR | ALDH1A1 3368/4885LMNA 4004/4885MAPT 1658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.