Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 20/20 | 0.84 |
| ▸ | PPIB | P23284 | 7/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.79 |
| ▸ | PPIF | P30405 | 2/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.76 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.76 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.76 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.76 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.74 |
| ▸ | GMNN | O75496 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12994808 | 1.00 | PPIA (0.84) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL15183862 | 0.93 | PPIA (0.91) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL15383383 | 0.93 | PPIA (0.91) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL12994801 | 0.92 | PPIA (0.90) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL15383384 | 0.92 | PPIA (0.90) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL1708951 | 0.92 | PPIA (0.77) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL15383382 | 0.91 | PPIA (0.90) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL12994807 | 0.91 | PPIA (0.78) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL15183408 | 0.91 | PPIA (0.81) | PPIAPPIBCYP3A4CYP2C9PPIF | |
| SCHEMBL19861134 | 0.91 | PPIA (0.81) | PPIAPPIBCYP3A4CYP2C9PPIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200185-A1 | CYCLOSPORIN DERIVATIVES FOR TREATING OCULAR AND DERMAL DISEASES AND CONDITIONS | ALLERGAN, INC. (US) | 2014-07-17 | — | — | US | disclosed |
| US-8716238-B2 | Cyclosporin derivatives for treating ocular and dermal diseases and conditions | ALLERGAN, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-8524671-B2 | Cyclosporin derivatives for treating inflammatory diseases and conditions | ALLERGAN, INC (US) | 2013-09-03 | — | — | US | disclosed |
| US-20100305047-A1 | CYCLOSPORIN DERIVATIVES FOR ENHANCING THE GROWTH OF HAIR | ALLERGAN, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305037-A1 | CYCLOSPORIN DERIVATIVES FOR TREATING INFLAMMATORY DISEASES AND CONDITIONS | ALLERGAN, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100009953-A1 | CYCLOSPORIN DERIVATIVES FOR TREATING OCULAR AND DERMAL DISEASES AND CONDITIONS | ALLERGAN, INC. (US) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009953-A1 | CYCLOSPORIN DERIVATIVES FOR TREATING OCULAR AND DERMAL DISEASES AND CONDITIONS | HRH4, HCAR3, NR1H4 | PPIA 2448/4885PPIB 2281/4885CYP3A4 637/4885 |
| US-20100305047-A1 | CYCLOSPORIN DERIVATIVES FOR ENHANCING THE GROWTH OF HAIR | ALK, MALT1, CYP21A2 | PPIA 710/4885PPIB 551/4885CYP3A4 677/4885 |
| US-20100305037-A1 | CYCLOSPORIN DERIVATIVES FOR TREATING INFLAMMATORY DISEASES AND CONDITIONS | MALT1, UACA, CD40 | PPIA 413/4885PPIB 440/4885CYP3A4 788/4885 |
| US-20140200185-A1 | CYCLOSPORIN DERIVATIVES FOR TREATING OCULAR AND DERMAL DISEASES AND CONDITIONS | HRH4, HCAR3, AHR | PPIA 2538/4885PPIB 2312/4885CYP3A4 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.