Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.51 |
| ▸ | TYMS | P04818 | 6/20 | 0.51 |
| ▸ | DHFR | P00374 | 6/20 | 0.51 |
| ▸ | FOLR2 | P14207 | 3/20 | 0.51 |
| ▸ | FOLR1 | P15328 | 3/20 | 0.51 |
| ▸ | SLC46A1 | Q96NT5 | 3/20 | 0.51 |
| ▸ | ATIC | P31939 | 2/20 | 0.51 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.51 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.51 |
| ▸ | FRK | P42685 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27835031 | 0.92 | DHFR (0.57) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL371409 | 0.92 | DHFR (0.57) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL12370806 | 0.91 | DHFR (0.50) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL2756063 | 0.88 | DHFR (0.48) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL1236538 | 0.85 | TYMS (0.56) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL19623246 | 0.85 | TYMS (0.56) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL207059 | 0.84 | TYMS (0.50) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL23544600 | 0.82 | GART (0.65) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL19623252 | 0.82 | GART (0.65) | GARTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL28544651 | 0.82 | TYMS (0.55) | GARTTYMSDHFRFOLR2FOLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945645-B1 | CRYSTALLINE FORMS OF PEMETREXED DIACID AND PROCESSES FOR THE PREPARATION THEREOF | SICOR INC (US) | 2010-12-01 | — | — | EP | disclosed |