Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.48 |
| ▸ | TYMS | P04818 | 6/20 | 0.48 |
| ▸ | GART | P22102 | 5/20 | 0.48 |
| ▸ | ATIC | P31939 | 2/20 | 0.48 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.48 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.48 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.48 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370806 | 0.92 | DHFR (0.50) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL27835031 | 0.88 | DHFR (0.57) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL371409 | 0.88 | DHFR (0.57) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL13003773 | 0.88 | GART (0.51) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL1236538 | 0.82 | TYMS (0.56) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL19623246 | 0.82 | TYMS (0.56) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL207059 | 0.81 | TYMS (0.50) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL12238847 | 0.80 | TYMS (0.63) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL23544600 | 0.79 | GART (0.65) | DHFRTYMSGARTATICFOLR2 | |
| SCHEMBL19623252 | 0.79 | GART (0.65) | DHFRTYMSGARTATICFOLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088919-B2 | Crystalline forms of pemetrexed diacid and processes for the preparation thereof | SICOR INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2322526-A1 | Crystalline form of pemetrexed diacid and process for the preparation thereof | Sicor, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-2311838-A1 | Crystalline form of pemetrexed diacid and process for the preparation thereof | Sicor, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| EP-2305681-A1 | Crystalline form of pemetrexed diacid and process for the preparation thereof | Sicor, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2270013-A1 | Crystalline form of pemetrexed diacid and process for the preparation thereof | Sicor, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2270012-A1 | Crystalline form of pemetrexed diacid and process for the preparation thereof | Sicor, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2008021405-A1 | CRYSTALLINE FORMS OF PEMETREXED DIACID AND PROCESSES FOR THE PREPARATION THEREOF | SICOR INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080045711-A1 | Crystalline forms of pemetrexed diacid and processes for the preparation thereof | ASSIA CHEMICAL INDUSTRIES LTD. (IL) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045711-A1 | Crystalline forms of pemetrexed diacid and processes for the preparation thereof | DCTD, DPYD, TYMP | DHFR 6/4885TYMS 9/4885GART 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.