Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14184585 | 0.89 | XDH (0.45) | XDH | |
| SCHEMBL13722986 | 0.84 | KDM4E (0.42) | XDHKDM4EASPHKDM8RXFP1 | |
| SCHEMBL13723419 | 0.81 | KDM4E (0.45) | XDHKDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL13139799 | 0.81 | XDH (0.46) | XDHKDM4EGRM5ALDH1A1HTT | |
| SCHEMBL16313328 | 0.81 | KDM4E (0.40) | XDHKDM4EASPHKDM8 | |
| SCHEMBL13118031 | 0.79 | KDM4E (0.42) | KDM4EASPHKDM8ALDH1A1LMNA | |
| SCHEMBL13004433 | 0.77 | XDH (0.47) | XDHKDM4EASPHKDM8 | |
| SCHEMBL14384228 | 0.77 | XDH (0.52) | XDHKDM4EALDH1A1HTTLMNA | |
| SCHEMBL1329694 | 0.75 | XDH (0.54) | XDHKDM4E | |
| SCHEMBL1329554 | 0.74 | XDH (0.53) | XDHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1932832-B1 | TRIARYLCARBOXYLIC ACID DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2010-12-01 | — | — | EP | disclosed |
| EP-1932832-A1 | TRIARYLCARBOXYLIC ACID DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-06-18 | — | — | EP | disclosed |