Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12102757 | 0.89 | MET (0.53) | METKDRROCK2ROCK1CHEK1 | |
| SCHEMBL12102756 | 0.87 | MET (0.65) | MET | |
| SCHEMBL1300872 | 0.87 | MET (0.52) | METROCK2ROCK1NPC1RAB9A | |
| SCHEMBL1301458 | 0.87 | MET (0.52) | METGSK3B | |
| SCHEMBL1300839 | 0.85 | MET (0.50) | METROCK2ROCK1 | |
| SCHEMBL1300549 | 0.82 | MET (0.50) | METROCK2ROCK1FLT3 | |
| SCHEMBL1951931 | 0.81 | MET (0.51) | METIRAK4IRAK1KDRPRKAB2 | |
| SCHEMBL1301108 | 0.81 | SIGMAR1 (0.51) | METROCK2ROCK1 | |
| Emd-1204831 SCHEMBL2350245 | 0.78 | MET (0.75) | MET | |
| Phosphoric Acid SCHEMBL2354953 | 0.75 | MET (0.53) | METIRAK4IRAK1KDRROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877751-B2 | Benzothiazolone derivatives | MERCK PATENT GMBH (DE) | 2014-11-04 | — | — | US | claimed |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-03 | — | — | US | claimed |
| US-8877751-B2 | Benzothiazolone derivatives | MERCK PATENT GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-8877751-B2 | Benzothiazolone derivatives | MERCK PATENT GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-8877751-B2 | Benzothiazolone derivatives | MERCK PATENT GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-03 | — | — | US | disclosed |
| EP-2373635-A1 | BENZOTHIAZOLONE DERIVATIVE | Merck Patent GmbH (DE) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010078905-A1 | BENZOTHIAZOLONE DERIVATIVE | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | RET, JAK2, MET | MET 3/4885IRAK4 272/4885IRAK1 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.