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Sugi Predict / Compounds / SCHEMBL13005178

SCHEMBL13005178

SCHEMBL13005178

CC(C)(C)OC(=O)N1CCS[C@H]1C(=O)N[C@@H](CCO)c1ccc(F)cc1F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4D Q6B0I6 1/20 0.37
▸ GPR119 Q8TDV5 2/20 0.37
▸ TACR1 P25103 3/20 0.35
▸ JAK2 O60674 1/20 0.35
▸ JAK1 P23458 1/20 0.35
▸ TYK2 P29597 1/20 0.35
▸ JAK3 P52333 1/20 0.35
▸ NR1H2 P55055 1/20 0.35
▸ NR1H3 Q13133 1/20 0.35
▸ MDM4 O15151 1/20 0.34
▸ MDM2 Q00987 1/20 0.34
▸ GHSR Q92847 1/20 0.34
▸ PTGFR P43088 1/20 0.34
▸ CFD P00746 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ BRD3 Q15059 1/20 0.33
▸ APP P05067 1/20 0.33
▸ HTR1A P08908 1/20 0.33
▸ ADRA2A P08913 1/20 0.33
▸ DRD2 P14416 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13715039 0.88 PTGFR (0.43) GPR119TACR1NR1H2NR1H3PTGFR
SCHEMBL18055685 0.88 PTGFR (0.43) GPR119TACR1NR1H2NR1H3PTGFR
SCHEMBL3383891 0.86 JAK2 (0.38) JAK2JAK1TYK2JAK3PTGFR
SCHEMBL13005180 0.84 GPR119 (0.38) GPR119NR1H2NR1H3GHSRPTGFR
SCHEMBL3385956 0.82 PTGFR (0.39) TACR1PTGFR
SCHEMBL3386859 0.82 PTGFR (0.39) TACR1PTGFR
SCHEMBL13004626 0.82 PTGFR (0.39) TACR1PTGFR
SCHEMBL19118652 0.78 PTGFR (0.40) GPR119TACR1NR1H2NR1H3PTGFR
SCHEMBL3382903 0.76 RIPK1 (0.46) PTGFRCFD
SCHEMBL3383657 0.73 PTGFR (0.59) PTGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8415480-B2 Thiazolidine carboxamide derivatives as modulators of the prostaglandin F receptor MERCK SERONO SA (CH) 2013-04-09 — — US disclosed
US-8415480-B2 Thiazolidine carboxamide derivatives as modulators of the prostaglandin F receptor MERCK SERONO SA (CH) 2013-04-09 — — US disclosed
EP-1487442-B1 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR MERCK SERONO SA (CH) 2010-12-01 — — EP disclosed
US-20090215749-A9 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR LABORATOIRES SERONO S.A. (CH) 2009-08-27 — — US disclosed
US-20090215749-A9 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR LABORATOIRES SERONO S.A. (CH) 2009-08-27 — — US disclosed
US-20080255094-A1 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR LABORATOIRES SERONO S.A. (CH) 2008-10-16 — — US disclosed
US-20080255094-A1 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR LABORATOIRES SERONO S.A. (CH) 2008-10-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215749-A9 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR PTGER4, PTGER2, PTGER1 KDM4D 2954/4885GPR119 406/4885TACR1 456/4885
US-20080255094-A1 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR PTGER4, PTGER2, PTGER1 KDM4D 2954/4885GPR119 406/4885TACR1 456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.