Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005239 | 0.98 | HRH3 (0.47) | HRH3ALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL14608917 | 0.87 | HRH3 (0.47) | HRH3ALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL3771811 | 0.87 | HRH3 (0.67) | HRH3ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3776097 | 0.85 | HRH3 (0.64) | HRH3ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL3768876 | 0.82 | KMT2A (0.56) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL13004952 | 0.81 | KDM4E (0.67) | ALDH1A1KDM4ETDP1MAPTSMN1; SMN2 | |
| SCHEMBL13004958 | 0.80 | KMT2A (0.56) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL3770906 | 0.79 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL13004950 | 0.79 | ALDH1A1 (0.63) | HRH3ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL3766221 | 0.79 | KDM4E (0.53) | HRH3ALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851474-B2 | Dipiperazinyl ketones and related analogues | NEUROGEN CORPORATION (US) | 2010-12-14 | — | — | US | disclosed |
| US-20070049571-A1 | Dipiperazinyl ketones and related analogues | NEUROGEN CORPORATION | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049571-A1 | Dipiperazinyl ketones and related analogues | HRH4, HRH3, HRH1 | HRH3 2/4885ALDH1A1 1210/4885KDM4E 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.